av手机在线观看一区二区三区 ,一色桃子中文字幕人妻熟女作品,欧洲老妇60一70

Release date：2019-11-15

Molecular Immunology

[IF:3.064]

Allergen component analysis as a tool in the diagnosis and management of occupational allergy
https://doi.org/10.1016/j.molimm.2018.03.013
Highlights
More than 400 occupational sensitizers are identified, but only a limited number of them are characterized on the molecular level.
Natural rubber latex (NRL) allergy is an excellent model for improving sIgE measurement with recombinant major allergen.
IgE-sensitization profile in patients with baker’s asthma showed great inter-individual variation.
For diagnosis of baker’s asthma extract-based diagnostic is still recommended.
Increasing the knowledge of occupational allergens and implement and evaluate standardized tools in clinical practice is necessary.
Abstract
We are now in the epoch of “molecular allergology” and numerous clinically relevant allergenic molecules are available improving the performance of in vitro allergen tests and allergen detection methods. This review is focusing on characterized occupational allergens and their implementation into the in vitro diagnosis for occupational allergy and in allergen detection methods.
More than 400 occupational agents are identified and documented as being ‘respiratory sensitizers’, but currently only a limited number of them are characterized on the molecular level and available for routine diagnosis as native or recombinant allergens. One exception, however, is natural rubber latex (NRL) from Hevea brasiliensis still remaining an important occupational allergen source.
Characterization of 15 NRL allergens led to the development of assays for the determination of allergen content of NRL materials and the implementation of component-resolved diagnosis (CRD) for specific IgE antibody measurement. Microarray or singleplex using recombinant or native allergens are reliable tools for NRL allergy diagnosis.
In addition, NRL allergy is an excellent model for improving extract-based specific IgE measurement by amplification of NRL extract preparation with stable recombinant major allergen rHev b 5. Despite the many efforts to characterize the occupationally relevant wheat allergens for baker’s asthma, the most frequently occurring forms of occupational asthma, the results are highly diverse.
Wheat sensitization profiles of bakers showed great interindividual variability and no wheat allergen could be classified as the major allergen. For diagnosis of baker’s asthma, a whole wheat extract is still the best option for specific IgE determination. But single wheat allergens might help to discriminate between wheat-induced food allergy, grass pollen allergy and baker’s asthma. For workplace-related allergens like coffee, wood, soybean, seafood and moulds allergens are characterized and few of them are available, but their relevance for occupational sensitization routes should be verified in the further studies.
Author:
MonikaRaulf

2019-12- 24 Review

Hangzhou Zheda Dixun Biological Gene Engineering Co., Ltd. Copyright HZKC Technical support 浙ICP備14005341號(hào) （浙）-非經(jīng)營(yíng)性-2019-0050

Address: Rm.201-209, Bldg.2, No.568 Binkang Rd., Binjiang Dist. Tel: 0571-87968248-805 Website:m.avast-downloads.com

Official WeChat

欧美va亚州ⅴa在线观看,国产AV无码熟妇人妻麻豆,国产肥熟女老太老妇A片,狠色鲁很很鲁在线视频,披黑人猛躁10次高潮,欧美精品久久久久自慰,风韵丰满熟妇啪啪熟女

杭州浙大迪迅生物基因工程有限公司

Release date：2019-11-15